Adolor cuts 30 jobs as Entereg sales falter

Exton, PA-based Adolor is cutting 30 jobs, or about a third of its workforce, as it attempts to reduce cash burn levels. The developer had 114 employees at the end of 2009. In May 2008, the FDA approved Entereg for postoperative ileus, a common condition following surgery that can extend a patient's hospital stay. It was the first approval for Adolor, which was partnered with GlaxoSmithKline on the treatment. Sales of the drug have been slow since it launched in 2009. Second quarter sales of...

Adolor shares sink after placebo effect scuttles PhIIa pain trial

Shares of Adolor (ADLR) took an 18 percent dive yesterday evening after the company announced that two of its pain meds partnered with Pfizer had failed a mid-stage clinical trial. Pfizer paid $30 million upfront to collaborate on ADL5859 or ADL5747, two therapies that were tested alongside oxycodone for its effectiveness in reducing pain among patients with osteoarthritis. Exton, PA-based Adolor said that an unusually high placebo response eliminated any statistically significant drug...